Listen to the E, M, N, ORF, & S genes from the recently sequenced SARS-CoV-2 genome. The 21 different amino acids are assigned various notes. Each single letter represents an amino acid.
M Gene Artwonk 3 Biovoice mp3 created with Artwonk freeware An incredible piece of software developed by the late John Dunn and his geneticist wife Dr. Mary Anne Clark
E GENE The notes are arranged in C Major scale (see chart below) aa sequence (75 aa = 75 musical notes) 1 mysfvseetg tlivnsvllf lafvvfllvt lailtalrlc ayccnivnvs lvkpsfyvys 61 rvknlnssrv pdllv E Gene of the SARS-CoV-2 Virus 18 March 2020 C Major musical Scale used to create this sheet music (Bio2MIDI freeware)
ORF6 - Voice Oohs mp3 Open Reading Frame 6 protein Source ORF6 created with Bio2MIDI freeware aa sequence 1 mfhlvdfqvt iaeilliimr tfkvsiwnld yiinliiknl sksltenkys qldeeqpmei 61 d
ORF10 Gene - Bowed Glass Listen here ORF10 Gene mp3 Open Reading Frame 10 Gene Amino Acid Sequence Source: GenBank: MN908947.3 (created using Bio2MIDI freeware) MGYINVFAFPFTIYSLLLCRMNSRNYIAQVDVVNFNLT Open Reading Frame (ORF) If you are musically inclined, you know about triplets. Well triplets are like codons, which are 3 bases (see the example below of GAU in the mRNA)
Listen by clicking below N gene - brightness N ( nucleocapsid phosphoprotein) Gene Amino Acid Sequence Source: GenBank: MN908947.3 (created using Bio2MIDI freeware) MSDNGPQNQRNAPRITFGGPSDSTGSNQNGERSGARSKQRRPQG LPNNTASWFTALTQHGKEDLKFPRGQGVPINTNSSPDDQIGYYRRATRRIRGGDGKMK DLSPRWYFYYLGTGPEAGLPYGANKDGIIWVATEGALNTPKDHIGTRNPANNAAIVLQ LPQGTTLPKGFYAEGSRGGSQASSRSSSRSRNSSRNSTPGSSRGTSPARMAGNGGDAA LALLLLDRLNQLESKMSGKGQQQQGQTVTKKSAAEASKKPRQKRTATKAYNVTQAFGR RGPEQTQGNFGDQELIRQGTDYKHWPQIAQFAPSASAFFGMSRIGMEVTPSGTWLTYT GAIKLDDKDPNFKDQVILLNKHIDAYKTFPPTEPKKDKKKKADETQALPQRQKKQQTV TLLPAADLDDFSKQLQQSMSSADSTQA See the chart below to identify the single letter amino acids (shown in red circles).
From this aa sequence 1 madsngtitv eelkklleqw nlvigflflt wicllqfaya nrnrflyiik liflwllwpv 61 tlacfvlaav yrinwitggi aiamaclvgl mwlsyfiasf rlfartrsmw sfnpetnill 121 nvplhgtilt rplleselvi gavilrghlr iaghhlgrcd ikdlpkeitv atsrtlsyyk 181 lgasqrvagd sgfaaysryr ignyklntdh ssssdniall vq to this sheet music below Listen to this aa sequence by clicking below M gene harp Membrane glycoprotein Amino Acid Sequence Source: GenBank: MN908947.3 (created using Bio2MIDI freeware) MADSNGTITVEELKKLLEQWNLVIGFLFLTWICLLQFAYANRNR FLYIIKLIFLWLLWPVTLACFVLAAVYRINWITGGIAIAMACLVGLMWLSYFIASFRL FARTRSMWSFNPETNILLNVPLHGTILTRPLLESELVIGAVILRGHLRIAGHHLGRCD IKDLPKEITVATSRTLSYYKLGASQRVAGDSGFAAYSRYRIGNYKLNTDHSSSSDNIA LLVQ The single letter amino acid codes are shown in red circles in the chart below. From ScienceDirect: Matrix Proteins The term...
Listen by clicking below E Gene in mp3 format E gene (envelope gene - a structural protein located in the envelope or shell of the virus) Envelope protein amino acid sequence Source: GenBank: MN908947.3 (created using Bio2MIDI freeware) MYSFVSEETGTLIVNSVLLFLAFVVFLLVTLAILTALRLCAYCCNIVNVSLVKPSFYVYSRVKNLNSSRVPDLLV The single letter amino acid codes are shown in red circles in the chart below.